Mechanomics project has been recently funded by CR-UK and it is a three year research project (£300K). The project is led by Dr Marc Chadeau-Hyam at the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, but it operates in close collaboration with international partners from leading groups in cancer epidemiology: the University of Utrecht (the Netherlands), the Arctic University of Tromso (Norway), the International Agency for Research on Cancer (IARC, France), Maastricht University (the Netherlands), Queensland University of Technology (Australia), Dartmouth University (USA), and the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital (Canada), and is linked to two large lung cancer consortia ILCCO and TRICL.
The project will build upon already available genotype data (N=45,000), genome-wide blood-derived DNA-methylation (N=2,700) and gene expression (N=700 of which 300 are already available) data. The project will devise novel statistical approaches combining OMICs profiling techniques, network topologies, and longitudinal models to explore the molecular mechanisms involved in the smoking-induced cellular perturbations using the wealth of multi OMICs profiles available in healthy participants.
Altogether the proposed research will help identifying functionally relevant OMICs biomarkers mediating the effect of exposure to tobacco smoke towards increased risk of lung cancer, and will potentially inform both their role in lung carcinogenesis, and their ability to predict dynamics of lung cancer progression. As such Mechanomics has the potential to contribute to improved patients early diagnosis and risk stratification.